The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1

NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies - ScienceDirect

A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death - ScienceDirect

NAD+ Inhibits Protein that Promotes Neuron Degeneration

The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity? - Sarkar - 2023 - The FEBS Journal - Wiley Online Library

Dr. Jing Yang's Lab: The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1 - IDG/McGovern Institute for Brain Research at PKU

Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders

The NAD-mediated self-inhibition mechanism of pro-neurodegenerative SARM1

SARM1-Dependent Axon Degeneration: Nucleotide Signaling, Neurodegenerative Disorders, Toxicity, and Therapeutic Opportunities - Helen Y. McGuinness, Weixi Gu, Yun Shi, Bostjan Kobe, Thomas Ve, 2023

RCSB PDB - 7CM7: NAD+-bound Sarm1 E642A in the self-inhibited state

SARM1 activation and its downstream pathways are distinct in neuronal compartments

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1

Acidic pH irreversibly activates the signaling enzyme SARM1 - Zhao - 2021 - The FEBS Journal - Wiley Online Library